Synthesis and Characterization of Al2O3-Loaded Ofloxacin nanoparticles to Combat Salmonella Typhi Bacteria

Abstract

Nanomaterials that include inorganic metallic ions are frequently used in the treatment of a wide range of diseases, including cancer, autoimmune disorders, and the colonization of bacteria and fungi. The purpose of this research was to investigate the usage of Al₂O₃-loaded ofloxacin nanoparticles (AOFNs) as an antibacterial agent. FTIR, SEM and TEM, were utilized to investigate the nanocarriers that were created via adsorption. When conducting in vitro release tests at 37 ^◦C, simulated bodily fluid was utilized. When the data were analyzed with some different kinetic models, it was discovered that the dissolution was slow and took between 12 and 24 hours. An increase in the effectiveness of antimicrobial agents against Salmonella Typhi  was discovered through research investigations. An experimental investigation revealed that AOFNs had a particle size of 233 nm, a zeta potential value of -41.98 mV, and a good encapsulation effectiveness of 89-93%. These characteristics were discovered by the results of the experiment.