Formulation and Development of Controlled Released Ocular Insert

Abstract

The primary goal of this study is to create flurbiprofen ocular inserts that are successful in preventing ocular infections. By increasing the medication's bioavailability through prolonged drug-eye contact times and regulating trans-corneal drug penetration, these inserts can improve ocular therapy. Our goal is to optimize the formulation to demonstrate a continuous release of the medicine, allowing for the maintenance of the dose for an extended duration. In order to do this, we created formulations of flurbiprofen ocular inserts using a variety of polymers, varying quantities of HPMC, ethyl cellulose, and a plasticizer called dibutyl phthalate. The produced formulations were assessed for stability, appearance, durability, v homogeneity of drug contents, in vitro and in vivo release of the drug, and other physical and analytical parameters. Flurbiprofen ocular implants were made using solvent casting.