Formulation & Characterization of Transdermal Patch of Ginger Extract

Abstract

This study focuses on the formulation and characterization of a transdermal patch containing ginger extract. Ginger (Zingiber officinale) is renowned for its bioactive compounds, particularly gingerols and shogaols, which exhibit significant medicinal benefits. The transdermal patch formulation involves the incorporation of ginger extract into a suitable polymer matrix to ensure controlled and sustained release of the active ingredients through the cellulose membrane. A combination of polymers, plasticizers, and permeation enhancers was evaluated to optimize the patch's mechanical properties, adhesiveness, and drug release profile. In vitro drug release studies were performed using Franz diffusion cells, and the results indicated that the transdermal patch effectively released ginger extract.

OBJECTIVES: To create a new dose form of the ginger extract containing transdermal patch.

METHODS: The ginger extract were collected by maceration method. The Mentha leaves were hydro-distilled to obtained the Mentha oil. The transdermal patch containing the ginger extract were prepared by the solvent casting method.

RESULTS: The optimized formulation demonstrated satisfactory tensile strength, uniform drug distribution, and prolonged drug release, making it a promising candidate for transdermal drug delivery systems.