Quercetin as an Epilepsy Disease Treatment and Its Nanotechnological Perspective

Abstract

A polyphenolic bioactive substance that is abundantly found in berries, nuts, vegetables, and fruits is quercetin. Many neurological disorders, including epilepsy, are known to benefit from quercetin and its derivatives, such as rutin and hyperoside. The clinical studies of quercetin and its derivatives in relation to epilepsy are limited. This review provides the evidence of most recent knowledge of anticonvulsant properties of quercetin and its derivatives on preclinical studies. Additionally, the studies demonstrating antiseizure potential of various plants extracts enriched with quercetin and its derivatives has been included in this review. Here, we've also covered the bioactive compounds neuroprotective effects and provided a brief overview of the underlying processes causing their anticonvulsant effects. Lastly, the limits of quercetin and its derivatives as drugs that prevent seizures as well as potential methods to increase their effectiveness have also been covered.