The Study of Thyroid Function Tests in Chronic Heart Failure & To Also Know the Correlation Between Tft and Troponins I and T/Bnp And Nt-Pro Bnp

Abstract

Background: Thyroid hormone regulates cardiovascular functions by impacting the myocardium, conduction system, and peripheral vasculature. Its deficiency can lead to hyperlipidemia and ventricular arrhythmias, while excess can cause atrial arrhythmias, hypertension, and heart failure. However, treating the underlying thyroid condition can typically reverse these abnormalities. Patients with subclinical thyroid dysfunction often have FT4 levels within the reference range, but abnormal TSH levels, indicating that the amount of thyroid hormone present is not optimal for that individual.

Materials & Methods: This is hospital based cross sectional observational study which was conducted in the  Department of general medicine of Private medical college with study period of 6 months. The total sample size of the study was 50 patients. The collected data was entered in Microsoft Excel. Coding of the variables was done. Analysis was done using SPSS software (Version 27, IBM).

 Results: Among the 50 patients, (30%) were males and (75%) were females. Age between 51 and 60 years 40%,  41 to 50 years, 26%. Patients over 60 years account for 16%, while 14% are in the 31 to 40 years age, 30 years, represents only 4%. Comorbidities were 40% of hypertension, 30% diabetes mellitus, and 18% hyperlipidemia and 12% have chronic kidney injury

Conclusion: Our study shows that subclinical hypothyroidism with a TSH level of ≥7 mIU/L and low T3 syndrome are negative prognostic factors for ambulatory heart failure patients. This underscores the need to explore the potential therapeutic benefits of T4 and T3 administration in heart failure patients.