The Correlation Of Covid Vaccine Types Administration To Menstrual Disturbances

Abstract

Background: As a form of prevention of COVID-19, there are various types of vaccines developed and which have been disseminated in Indonesia and approved by BPOM, there are 5, namely Sinovac, AstraZeneca, Sinopharm, Pfizer and Moderna. However, there have been some reports that COVID-19 vaccines cause a number of menstrual disturbances, including irregular cycles, cramps and bleeding. The menstrual cycle is regulated by  the hypothalamic-pituitary-ovarian axis which can be affected by life, environmental, and health stressors. COVID-19 vaccines can create a strong immune response or stressor, temporarily affecting the hypothalamic-pituitary-ovarian axis, and causing menstrual disturbances.

Research Objectives: To find out whether there is a relationship between the administration of the COVID-19 vaccine and menstrual disturbances in female students of the Faculty of Medicine, University of Pelita Harapan.

Research Methods: The study was conducted based on an unpaired comparative analytical observation study with a cross-sectional study and was carried out in January-April 2023 at the Faculty of Medicine, University of Pelita Harapan, with a statistical testing method using the chi-square method.

Result: From the 123 respondents to the inclusion criteria, 114 (92.7%) female students did not experience menstrual disturbances after COVID-19 vaccination, while 9 (7.3%) other female students experienced menstrual disturbances. From the total 9 (7.3%) female students who experienced menstrual disturbances, the disturbances that occurred were menstrual duration disturbances, menstrual volume disturbances, and menstrual regularization disturbances. Based on the Chi-Square test, a p-value of 0.618 was obtained so that the P-Value> 0.05 and showed no relationship between the administration of the COVID-19 Vaccine type against menstrual disturbances.

Conclusion: There is no significant relationship between the administration of the COVID-19 Vaccine type against menstrual disturbances in female students of the Faculty of Medicine, University of Pelita Harapan.