Microneedling with PRP Versus Microneedling with Vitamin C in Treating Atrophic Post Acne Scars: A Comparative Split Face Study

Abstract

Background: Atrophic post-acne scars are a common and distressing condition that can significantly impact an individual's quality of life. Various treatments have been proposed, with microneedling being a popular choice due to its effectiveness in stimulating dermal healing. Platelet-rich plasma (PRP) and Vitamin C are commonly used adjuncts with microneedling, each offering unique benefits in skin rejuvenation. This study aimed to compare the efficacy and safety of microneedling with PRP versus microneedling with Vitamin C in the treatment of atrophic post-acne scars.

Methods: A total of 36 patients with bilateral atrophic facial acne scars were enrolled in this split-face, single-center, randomized study. Each participant received microneedling with PRP on one half of the face and microneedling with Vitamin C on the other half. The primary outcome was the improvement in scar appearance measured by the Melasma Area and Severity Index (MASI) scores at baseline, and at 4-, 8-, and 12-weeks post-treatment. Secondary outcomes included patient satisfaction and adverse effects.

Results: Both treatments significantly reduced MASI scores from baseline; however, the PRP treatment side showed a more significant improvement compared to the Vitamin C side. At the 8-week follow-up, the PRP group had a mean MASI score reduction of 60% compared to 45% in the Vitamin C group. Additionally, relapse rates post-treatment was lower in the PRP group. Patient satisfaction was significantly higher in the PRP group, and side effects were minimal and transient in both groups.

Conclusion: Microneedling with PRP proved to be more effective than microneedling with Vitamin C in improving the appearance of atrophic post-acne scars. PRP treatment led to greater and more sustained improvements in scar depth and skin texture, with higher patient satisfaction and lower relapse rates. These findings suggest that microneedling with PRP could be considered a preferable option for treating atrophic post-acne scars. Future studies with larger sample sizes and longer follow-up periods are recommended to confirm these results and further refine treatment protocols.