The Effect of an Oral Spray Containing an Extract of Pineapple (Bromelain) on Dental Plaque and Gingival Inflammation in Children: A Crossover Randomized Controlled Study

Abstract

Background: To investigate if daily use of an oral spray containing an extract of pineapple (bromelain), associated with supervised toothbrushing may improve gingival health in children with mixed dentition.

Method:  22 healthy children aged 6-12 years were included in the study where 2 groups where they were given bromelain spray and an unidentifiable placebo spray. Following an oral prophylaxis the study commenced; use of spray for 14 days after which the parameters (plaque index and gingial inflammation index) were recorded, followed by a washout period (8 days) and then crossover of another 14 days. Parameters were recorded again and compared. 

Results: Plaque index and gingival inflammation index were significantly lower in bromelain group as compared to placebo groups after 14 days p <0.001. Conclusions: Study indicates the correlation of active bromelain with reducing the gingival inflammation significantly. Bromelain spray can serve as a potential adjunct in maintaing the oral hygiene of children especially who are physically incapable of expectorating mouthwashes as well as fluoridated dentifrices while brushing their teeth