Formulation and Development of Thermosensitive in Situ Gel of Aspirin Containing Nanoparticles for Opthalmic Use

Abstract

A lot of researchers have recently become interested in aqueous polymer solutions that become gels due to changes in environmental factors like pH and temperature. This process, entitled "in situ hydrogel," is of scientific significance and has potential uses in the medicine or healthcare industries. When the hydrogel is produced under physiological conditions and keeps intact for the desired length of time, the technique may offer a number of advantages over conventional hydrogels. Drugs that are hydrophobic can be solubilized and delivered with controlled release using the in-situ gel formulation. These advantages derive from the ease of drug formulation through solution mixing biological compatibility with biological processes, and simple administration. Once the compatibility prove, the produced gel will give further benefits for in vivo applications that need breakdown, resulting in non-toxic degradation products. A summary of polymer systems that go through solution-gel formation, particularly those triggered by temperature variations, is useful right now. The emphasis should be on the underlying processes of these transformations and the various delivery options.