Comparative Study Between Infusion Fentanyl and Magnesium Sulphate in Attenuation of Hemodynamic Response During Laryngoscopy and Intubation

Abstract

Background: Laryngoscopy & endotracheal intubation are an integral part of general anaesthesia. There is increase in heart rate and blood pressure as a sequel of direct laryngeoscopy and endotracheal intubation. Fentanyl a synthetic μ-receptor agonist is used to attenuate the laryngoscopy & intubation response. Magnesium sulphate(MgSO4) is a cerebral depressant, is used to attenuate intubation-induced vasopressor response.

Aims & Objectives: 1. To compare the efficacy of IV infusion Fentanyl 2μg/kg and MgSO4 20mg/kg in the attenuation of hemodynamic response to laryngoscopy & intubation.

1. To evaluate any side effects associated with the use of these drugs.

Materials and Methods:A prospective randomized study was conducted on 100 ASA grade I and II patients of either sex between the age group 18-60 years undergoing elective and emergency surgeries under general anaesthesia. The study population was divided into 2 groups with 50 patients in each group. Group F received IV infusion Fentanyl 2μg/kg dose in 20cc NS over 10 mins in infusion pump. Group M received IV infusion MgSO4 20mg/kg dose in 20cc NS over 10 mins in infusion pump.

Results: The heart rate, systolic & diastolic blood pressure, mean arterial pressure decreased in both the groups receiving MgSO4 & Fentanyl. The response to laryngoscopy and intubation with increased parameters was seen in both groups, greater increase in fentanyl as compared to MgSO4.

Conclusion:Both Fentanyl and MgSO4 are effective in the hemodynamic attenuation during laryngoscopy, MgSO4 significantly & effectively attenuates hemodynamic responses & intubation in comparison to fentanyl.