Prospective Observational Study on Clinical and Biochemical Investigations Of Ethanol Induced Liver Diseases

Abstract

Alcoholic liver disease (ALD) is a growing concern globally, with increasing rates of illness and death. The prognosis of ALD depends on several factors, including the extent of liver damage, the presence of complications, and the duration and quantity of alcohol consumption. This summary aims to provide an overview of the current evidence on the clinical and biochemical features of ALD, including how mortality is evaluated using the Model for End-Stage Liver Disease (MELD) score and Child-Pugh score among ALD patients. Clinical studies have shed light on the multifaceted nature of ALD, spanning various stages from steatosis to steatohepatitis, fibrosis, cirrhosis, and even hepatocellular carcinoma. Biochemical investigations have uncovered underlying mechanisms of ALD pathogenesis, such as oxidative stress, inflammation, and disruptions in lipid metabolism. Additionally, research emphasizes the critical importance of early detection and intervention to halt disease progression. We collected data on patient demographics, alcohol consumption, liver function tests, MELD score, Child-Pugh score, and mortality rates.