Novel Review on Anti-Acne Plant Medicines: Their Significance for Contemporary Therapies

Abstract

Acne is a common but serious skin disease, which affects approximately 80% adolescents and young adults in 11–30 age group. from the beginning until their twenties, 50.9% of women and 42.5% of men still have this illness. The overuse of antibiotics has led to an alarming level of bacterial resistance. Therefore, the need of the hour is to find new lead molecules or bioactives and to strategically deliver the current medication to the site of action for improved therapeutic effect. Since the beginning of time, plants and products derived from them have played a crucial role in the health care system. Thus, the current review summarizes plants that have high potential and those that are currently used to treat acne. The most potent plant extracts against P. acnes are P. granatum, M. alba, A. anomala, and M. aquifolium, which have minimum inhibitory concentrations (MICs) between 4 and 50 µg/mL. Meanwhile, the aromatic oils of C. obovoides, C. natsudaidai, C. japonica, and C. nardus have MICs between 0.005 and 0.6 μL/mL, and phytomolecules like rhodomyrtone, pulsaquinone, hydropulsaquinone, honokiol, magnolol, xanthohumol lupulones, chebulagic acid, and rhinacanthin-C have MICs between 0.5 and 12.5. Novel approaches to delivering significant plant leads for the treatment of acne have also been explored.