An Investigation of Several Methodologies for Predicting the Solubility of Organic Compounds

Abstract

One of the most important factors in achieving the desired concentration of drug in the systemic circulation for the desired pharmacological reaction is solubility, which is the process of solute in solvent to give a homogenous framework. Inadequate permeability solubility may be the cause of the bioavailability problem. The solubility problems affect the majority of mixed solutions. Therefore, as synthetic science advances, there is an increasing need for improved drug inventions. Homogeneous liquid phases with factor proportions of solute and solvent are expressed by the solute-solvent interaction mechanisms. The medication property, the retention site, and the necessary measurement structure attribute all influence the choice of solubility improvement technique.