Microwave Assisted Synthesis and Biological Screening of Mannich Bases

Abstract

The microwave-assisted synthesis of 3-methyl 5-pyrazolone was performed by using ethyl acetoacetate and hydrazine hydrate. It was then reacted with different aromatic amines under microwave irradiation to obtain different Mannich bases. The synthesized compounds were characterized by MP, TLC, & FT-IR. All synthesized compounds were screened for anthelmintic activity using Pheretima posthuma (Indian earthworm) Time of paralysis (TOP) and Time of death (TOD) were reported. Albendazole was used as a standard. Synthesized compounds showed moderate to good activity.