A Study on Extended Drug Release Characteristics: Design, Development and Characterization of Metformin Hcl Loaded Gastroretentive Beads Using Ionic-Gelation Method

Abstract

This study aims to develop Metformin-loaded beads with controlled drug release by combining polymers such as Hydroxypropyl Methylcellulose (HPMC) K4M, HPMC K100M, Eudragit RL100, and sodium alginate. HPMC K4M & K100M are cellulose derivatives commonly used as matrix formers in sustained-release formulations. HPMC polymers provide controlled release of the drug by forming a gel layer upon contact with water, regulating drug diffusion. They offer versatility in controlling drug release kinetics by adjusting polymer concentration and viscosity. Eudragit polymers, including RL100, are acrylic-based polymers often employed in controlled-release formulations. Eudragit RL100 can enhance drug stability and prevent premature drug release in acidic environments, ensuring targeted delivery. Sodium alginate is strategically included to enable bead floatation, facilitating sustained drug release in a gastro retentive drug delivery system (GRDDS), is also known for its excellent biocompatibility and biodegradability. The beads undergo comprehensive in vitro evaluation, including buoyancy, drug content uniformity, and dissolution profiling. Findings suggest the potential of these beads for prolonged Metformin delivery in the gastrointestinal tract, with sodium alginate enhancing both buoyancy and overall GRDDS effectiveness, promising benefits in diabetes management.