Design and Development of Herbal Based Hydrophilic Ointment and Gel to Control Zoonotic Bacterial Diseases Transmitted by Dog Bites

Abstract

Introduction: Creature nibbles are critical reasons for dismalness and mortality around the world, because of the exchange of microorganisms through salivation that prompts a few deadly diseases.

Objectives: The current investigation revolves around the bacterial disease spread through canine chomps. 

Methods: The bacterial strains were screened based on their morphology, biochemical characters, and 16s ribosomal RNA by single-pass sequencing.

Results: The new strains publicized were Enterobacter hormaechei, Bacillus cereus, and Aeromonas veronii. The antibiogram examination of MBC and MIC with various concentrates of Datura metel leaf and Calotropis gigantea blossom shows the most noteworthy action against each of the three microbial detaches with various extents. The hydrophilic ointment created with 0.1 percent and 0.5 percent drug extract was more stable than the gel formulations in the Physiochemical investigation.

Conclusions: The gel formulation performed better in the Swelling Index, Extrudability, and Spreadability Tests, indicating that gel formulations may transport drugs more effectively than hydrophilic ointments.