Elucidation of Ameliorative Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid Through PPAR-Γ/MPO’S/ BDNF Regulation in Diabetic Neuropathy Rats

Abstract

Background: The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids, and pentacyclic triterpenic acids. Boswellic acids have been thoroughly investigated for their possible role in neuroprotection in an in-vivo model. Anti-diabetic effects via inhibition of DPP4 and GLP-1 and Insulin receptors can be potential biological targets of boswellic acid. Aim & Objective: To study the effect of 3-acetyl-11-keto-β- Boswellic acid in a high-fat diet (HFD) with Streptozotocin (STZ) induced diabetic neuropathy in rats. Methodology: Totally 5 groups of rats were used for the study. control, HFD+STZ-induction, Pioglitazone (10mg/kg), and 2 test groups (AKBA at 10 and 30 mg/kg). Behavioral studies such as Hot plate, Pin-prick, and Sciatic functional index and biochemical studies like Oxidative marker levels, Lipid marker levels, and Lipid peroxidation marker levels in Serum estimation were performed. Moreover, the histology of the Sciatic nerve and Pancreas were performed. Results: The administration of AKBA (10 and 30 mg/kg) reversed the changes in behavioral, biochemical, Lipid parameters, and Peroxidation levels in HFD+STZ-induced rats. Histopathological analysis demonstrated the improvement in the Sciatic nerve and Pancreas tissue on AKBA administration when compared to the control and negative control group. Conclusion: The study concludes that AKBA can be a potent drug to treat diabetic neuropathy induced by HFD+STZ-induced in rats.