Biodegradable Mucoadhesive Microspheres for Sustained Release of Therapeutic Agents Against H. Pylori: A Review of Recent Developments.

Abstract

A large percentage of people worldwide are afflicted with the common and chronic bacterial illness known as Helicobacter pylori (H. pylori). H. pylori may colonise the stomach mucosa and avoid the host immune response, making the development of effective treatment techniques to tackle the infection difficult. A potentially effective medication delivery method for the prolonged release of therapeutic drugs against H. pylori is the use of biodegradable Mucoadhesive microspheres.  An overview of current advancements in the area of biodegradable Mucoadhesive microspheres for the treatment of H. pylori infection is given in this article. A range of polymers, both synthetic and natural, have been studied in relation to the creation of Mucoadhesive microspheres. By adhering to the gastrointestinal mucosa, these microspheres may increase the bioavailability and retention period of the therapeutic compounds that are encapsulated. The article goes over the many techniques used to create biodegradable Mucoadhesive microspheres, such as ionotropic gelation, solvent evaporation, and emulsification. Furthermore, it emphasises the range of medicinal substances, including bismuth salts, proton pump inhibitors, and antibiotics, that have been included in these microspheres. This study offers a summary of the in vivo and in vitro investigations that assessed the effectiveness of biodegradable Mucoadhesive microspheres in treating H. pylori infection. These investigations have shown that Mucoadhesive microspheres may release therapeutic drugs over an extended period of time, improving therapeutic effects and lowering dose frequency.