Preformulation Studies of Atenolol Cardiovascular Lipid Nanocarrier Transferosome

Abstract

Physicochemical characteristics of drugs are assessed in preformulation studies in order to optimize the formulation parameters of novel drug delivery systems. To identify suitable carriers for lipid nanocarrier formulation, we first determined the solubility of atenolol in various solvents. UV-Visible spectrophotometry was used to construct a calibration curve for accurately quantifying atenolol concentrations. Atenolol was analyzed by FTIR to assess any chemical interactions between it and the components of the lipid nanocarrier, allowing insight into the formulation's stability and compatibility. Lastly, DSC was employed to determine the optimal processing conditions for atenolol and lipid nanocarrier by examining their thermal behavior and compatibility. Atenolol is more soluble in lipid-based carriers, which facilitates its incorporation into transferosomes. It was possible to measure atenolol in lipid nanocarrier formulations accurately thanks to the linearity of the calibration curve over a wide concentration range. According to the FTIR analysis, atenolol and lipid nanocarrier components have no significant chemical interactions, which ensures formulation stability. An optimization of formulation parameters was enabled by DSC analysis, which confirmed atenolol compatibility with the lipid nanocarrier.