Floating Drug Delivery System of Gastro Retentive Drug Delivery System

Abstract

Short stomach residence times and erratic emptying of the stomach times are among the physiological problems that have been resolved in recent years by scientific and technological breakthroughs in the study and creation of novel drug delivery techniques. Gastro-retentive drug delivery refers to dosage forms that are able to remain in the stomach. Some methods used to prolong the gastric residence period include swelling and expanding systems, floating drug delivery systems, polymeric bio-adhesive systems, high-density systems, along other delayed gastric emptying systems. The latest phase of medication-based therapy is emerging, wherein an increasing number of innovative drug delivery techniques are being utilized to render drugs appropriate for clinical application. Floating Drug Delivery Systems (FDDS) are among the most efficient gastro-retentive dosage forms used to provide an extended period of stomach gastric residence. The goal of this review was to compile the most recent studies on floating drug delivery systems (FDDS), with a particular emphasis on the primary floating mechanism that causes gastric retention. Long-acting oral dosage forms of medications that act locally all over the stomach and are absorbed from the upper part of the gastrointestinal tract have many benefits. The physiology, excipient variables that affect gastric retention, factors governing the duration of gastric retention, and methods for creating hydro- dynamically balanced single- and multi-unit floating structures are all covered in this review, an in-depth explanation of their classification, development, and assessment; and a few instances of how these systems are used.