Neuroprotective Potential of Calycosin, Naturally Occurring Isoflavones of Formononetin

Abstract

Flavonoids are structurally varied phytochemicals found in fruits, nuts, and vegetables, and have been linked to several health advantages. Calycosin is the most significant active flavonoid compound that is widely distributed in astragalus. various evidence suggests that calycosin exhibits anti-oxidant properties which are beneficial for neuroprotection. Calycosin has been specifically alleviated by modulating several neuroprotective pathways. In addition to this, calycosin modulates HMGB1/TLR4/NF-kappa B and NLRP3/NF-kappa B. Moreover, research indicates that calycosin promotes neuroprotection by the TRPC6/ P-CREB pathway. Besides, this calycosin also modulates neuronal apoptosis by inhibiting apoptotic protein and has another modulating action on oxidative stress and RASD1. Furthermore, several studies have reported anti-inflammatory and anti-oxidant properties of calycosin concerning neurodegenerative disease. The current review aims to provide a detailed analysis of calycosin on its mechanistic neuroprotective action.