Comparison of Heat Shock Protein (HSP)-70 and Interleukin-6 Levels Pre and Post Operation in Chronic Rhinosinusitis Patients

Abstract

Introduction: Chronic rhinosinusitis (CRS) is a long-term disorder marked by inflammation of the nose and paranasal sinus mucosa. HSP-70 can have a variety of immunological consequences on CRS, including the secretion of proinflammatory cytokines such as IL-6. HSP-70 and IL-6 may have an impact on the outcome of surgery.

Objective: To determine the comparison of HSP-70 and IL-6 levels before and after surgery in patients with chronic rhinosinusitis.

Methods: This is an observational analytical study with a prospective study design that will take place from May to October 2023. Patients with chronic rhinosinusitis who had functional endoscopic sinus surgery (FESS) and met the criteria of the European Position Paper on Rhinosinusitis and Nasal Polyps 2020 were included in this study. HSP-70 and IL-6 levels were measured in all individuals before and after FESS. SPSS 26.0 was used to analyze the data.

Results: 18 people were included in this study. 13 people (72.2%) were men and 5 people (27.8%) were women. 6 people (33.3%) were <= 35 years old, while the rest were > 35 years old. The mean IL-6 was found to be higher post-operatively (7.36±14.87) compared to pre-operatively (2.92±8.57) and The distinction was crucial (p=0.048). The mean HSP-70 was higher preoperatively (2.79±1.93) than postoperatively (2.06±2.60), However, the difference was insignificant (p=0.184).

Conclusion: HSP-70 levels in patients with CRS pre-operatively were higher than post-operatively. IL-6 levels in patients with CRS preoperatively were lower than postoperatively.