A Brief Review on Light Responsive Drug Delivery System as Personalized Medicine of Photodynamic Therapy and Over Years of Advancement on the Therapeutics

Abstract

Introduction -This review dredge into the foreground of personalized medicine within photodynamic therapy (PDT), focusing on the pivotal role played by light-responsive drug delivery systems. The exploration surrounds fundamental principles, spanning nanotechnology, biomaterials, and controlled release mechanisms. Beyond theoretical talks, interesting case examples covering a wide range of medical diseases are provided, highlighting the revolutionary potential of combining light-responsive medication delivery with personalised therapy.

Objectives-These studies highlight the adaptability and effectiveness of this strategy, especially when it comes to cancer therapy. To put it briefly, the purpose of this article is to provide researchers, clinicians, and pharmaceutical pioneers who are navigating the rapidly evolving field of light-responsive drug delivery systems with a succinct resource.

Methods - This is the comprehensive evaluation of literature from national and international journals. In this review ,we have used Elsevier, Science Direct ,Springer Link and website like Pub Med and Google Scholar to conduct literature search. The discussion covers the principles of PDT, emphasizing the importance of precise drug targeting and controlled release triggered by light. Most important factor that is the used of photosensitizer in the formulation of LRDDS is also mentioned and along with the carrier which is embed in it .Various strategies and technologies developed to enhance the efficacy and specificity of PDT through light-responsive drug delivery are reviewed.

Results- Photodynamic therapy (PDT) uses light-sensitive drugs to treat conditions like skin cancers, esophageal  cancer, and lung cancer by targeting and destroying cancer cells when activated by specific light. This therapy disrupts tumor blood vessels and can stimulate the immune system against cancer cells. Designing effective light-responsive drug delivery systems requires optimizing drug and light properties to minimize tissue damage while ensuring precise drug release upon light activation. Overcoming challenges like phototoxicity is essential for safe and effective use of these systems in therapy.

Conclusion- In summary, the progress in light-responsive drug delivery systems signifies a significant advancement in personalized medicine, particularly in photodynamic therapy (PDT). This evolution reflects the dynamic synergy between research and innovation in therapeutics. These sophisticated drug delivery systems exemplify the precision and customization achievable in modern medicine, as they are designed to respond to specific light triggers. By enhancing treatment effectiveness and minimizing off-target effects, the integration of light responsiveness into drug delivery offers a more patient-centered approach to therapy.