Effect of Different Concentrations of Sodium Hypochlorite in Single Visit Endodontic on Postoperative Pain: a Systematic Review.

Abstract

The review aims to evaluate the effectiveness of varying concentrations of sodium hypochlorite on postoperative pain following single-sitting root canal treatment. A thorough manual search was done on electronic databases namely PubMed, Scopus, and EBSCOhost. Only randomized clinical trials (RCTS) conducted between January 2000 to March 2024 were considered.  The studies that evaluated the pain levels at different time intervals following irrigation with varying concentrations of sodium hypochlorite (2.5% and 5.25%) after single-visit endodontics were included. Selected Items of Reporting for Systematic Reviews and Meta-Analysis checklists were utilized to set the review process. The checklist of critical appraisal for randomized controlled trials evolved by Joanna Briggs Institute was used in examining the risk of bias. The elementary search revealed 673 publications out of which 2 studies fulfilled the strict inclusion and exclusion criteria. One study showed that the incidence of postoperative pain using 5.25% Sodium hypochlorite is lower in contrast to 2.5%.  However, no remarkable variance in pain levels was observed in the other study. This systemic review concluded that there is inconclusive data available regarding postoperative pain with 2.5% and 5.25% sodium hypochlorite following single visit root canal treatment. Further clinical trials using similar preoperative conditions and treatment protocols are needed to determine a definitive association between postoperative pain and concentration of sodium hypochlorite.