Design and Evaluation of Controlled Released Tablets of Captopril in the Management of Hypertension by Using Karaya Gum as a Binder

Abstract

The present work aim to develop controlled-release tablets of Captopril by selecting different Types ofpolymers KarayaGum,Starch, and HPMC.A direct compression technique was adopted for the preparation of all these formulations.  Theblend of allthe formulations showed good flow properties such as angle of repose, bulk density, and tappeddensity.Thepreparedtabletsshowedgoodpost-compressionparametersandtheypassedall the quality control evaluation parameters as per I.P limits. Hardness, Friability, Weight Variation, in vitro dissolution study. Among all the developed batches F2 showed the highest drug release 98.30% at the end of 12 h. as compared to other formulations for the development of a controlled drug delivery system.