Invivo Evaluation of a Polyherbal Formulation in Streptozotocin-Induced Diabetic Rat

Abstract

Objective: To evaluate the invivo antidiabetic efficacy of a polyherbal formulation in streptozotocin-induced diabetic rat. Methods: Polyherbal formulation (PHF1) was tested for oral glucose tolerance test (OGTT) (2 h) in non-diabetic rats and antidiabetic activity (28 days) in non-diabetic and STZ-induced diabetic rats. Further, liver function test and kidney function test were also carried out. Results: The study demonstrate that Polyherbal formulation (PHF1) administered at a dosage of 400 mg/kg followed by 200 mg/kg exhibits significant antidiabetic activity. PHF1 significantly decreases the total cholesterol, triglyceride, LDL, VLDL level along with kidney function parameters. The data suggests that the PHF1 consistently improved hepatic and renal function in the treatment groups. The administration of PHF1 at a dosage of 400 mg/kg has demonstrated significant improvements in diabetic complications, indicating its efficacy as a therapeutic agent.

Conclusion: These findings suggest that PHF1 has the potential to serve as a source for the development of novel antidiabetic drugs.