Investigating the Impact of Intron Variant rs749292 in the CYP19A1 Gene on Cytotoxicity in Female Genetic Disorders

Abstract

This research explores the potential association between the intronic single nucleotide variant rs749292 in the CYP19A1 gene and the induction of cytotoxicity in the context of female genetic disorders. The overall analysis combining both stages demonstrates a significant deviation from Hardy-Weinberg equilibrium, ANOVA, and chi-square tests. Through an exploration of observed and expected frequencies of genotypes (GG, GA, AA) at different stages, along with a comprehensive analysis of chi-square values and determination of allele frequencies, we aim to elucidate the role of this specific variant in contributing to cellular stress and its implications for affected individuals.