Association of Components of Metabolic Syndrome in Patient with Chronic Kidney Disease with Diabetes Mellitus

Abstract

Objective: Patients with diabetes generally suffer from altered components of metabolic syndrome that further promote the risk of chronic kidney disease (CKD). The study will evaluate the association of diabetes with CKD on different metabolic parameters.

Methods: This cross-sectional study included 1,500 adult patients with type 2 DM and healthy controls who sought medical advice in the Department of Medicine at Hind Institute of Medical Sciences between February 2022 to August 2023. The patients considered for the study have gone through different parameters, such as measurement of albumin and eGFR and hence their result is drawn.

Results: The study conducted brings out the result that patients having more than 10 years of diabetes are prevalent to CKD .i.e. around 60%. Also was confirmed that impairment of eGFR with age was more prominent (92.18 ± 2.20 vs 54.19 ± 5.70 p<0.001).Low HDL levels of (30.92±4.95, vs 52.47±4.19 p<0.001) and high triglyceride levels (228.70 ± 47.82 vs 116.1±29.38 p<0.001) were linked to CKD. There were no statistically significant differences in the distribution of smokers and non-smokers between the control and CKD groups (p=0.687).

Conclusion: Our study demonstrated that approximately one-half of patients with type 2 DM had CKD. Further studies are necessary to understand this high prevalence and the underlying factors. Future research is needed to assess the effectiveness of implementing targeted community-based intervention.