Development and Evaluation of Nanocarrier for Delivery of Taxifolin Phytochemical.

Abstract

Introduction: The plant chemicals is called as phytochemicals which are used to prevent or suppress tumour, is known as chemoprevention. Many studies have been suggested and reported that numerous plant derived agents have anticancer potentials. As one such anticancer phytochemical Taxifolin which has several applications however that are limited due to its solubility.

Objectives: The aim of the present study was to design and evaluation of phytochemical based niosome of Taxifolin  as an effective nanocarrier for novel drug delivery system.

Methods: Taxifolin loaded into niosomes to increase its solubility and hence efficacy. Taxifolin loaded niosomes was prepared by thin film hydration method followed by sonication. The particle size, PDI, zeta potential, drug content, entrapment effectiveness, invitro drug release, scanning electron microscopy (SEM), and transmission electron microscopy TEM) were used to characterize the Taxifolin niosomes.

Results: The F6 formulation was chosen as optimized formulation based on particle size, zeta  potential, PDI and entrapment efficiency.  The particle size (115.8± 11.61 nm), PDI (0.191±0.98), zeta potential (-27.7±2.37 mV), loading efficiency (89.78±3.14) were studied.  In addition, the result of invitro release study indicated that cumulative release rate for pure Taxifolin and niosomes loaded Taxifolin were 71.18408 % and 96.85572 % after 24 hrs respectively.

Conclusions: The results demonstrated that niosomes increase the solubility of naturally derived       hydrophobic phytochemicals and thus enhance their therapeutic effect.