Improving Dissolution Rates of Low Solubility Pharmaceuticals Through Solid Dispersion Techniques

Abstract

The ability of a solute to dissolve in a solvent and produce solution. The original intent of the solid dispersion procedure was to distribute Water-soluble carriers for weakly water-soluble medicines, which enhanced the pharmaceuticals ‘dissolving characteristics and bioavailability. Strongly water-soluble drugs have poor dissolving qualities, which presents problems for pharmaceutical companies because the rate at which these drugs dissolve may also be the speed at which a drug's absorption in a solid dosage form is restricted. There are several methods for getting over low solubility one of them solid dispersion technique. This review aims to improve poorly soluble drug solubilization and bioavailability by using solid dispersion techniques. This review covers classification, carriers for solubility enhancement, and solid dispersion technique.