Synthesis and Characterization of Some Novel Fused Pyrimidine Derivatives

Abstract

Introduction: Fused pyrimidines are wonder moiety in the field of drug discovery and development that has caught attention of medicinal chemists owing to their facile chemical transformations and are known to exhibit various pharmacological properties as it is an inextricable part of physiological molecules including DNA & RNA. Pyrimidine-condensed compounds as the pharmacophore exhibits broader spectrum of therapeutic activities as it elicits synergistic action on the biological efficacy of the derivatives.

Objectives: The research work aims to synthesize some novel fused pyrimidine derivatives (SSR1-SS9) bearing various nitrogen containing substituents along with their spectral characterization using different techniques such as IR,¹H NMR, ¹³C NMR, LC-MS and Elemental analysis.

Methods: In this study, an attempt has been made to synthesize a series of nine fused pyrimidine derivatives using various substituted amines such as Allyl Amine, Ammonia, Hexylamine, Cyclopropylamine, 2-ethyl-1-hexyl Amine, Diethoxy ethylamine, Isobutyl amine, Benzyl amine and Cyclohexyl amine utilizing Ethyl(2Z)-2-(ethoxymethylidine)-3-oxobutanoate and S-methyl isothiouronium hemisulfate as starting materials.

Results: Structural analysis of the synthesized fused pyrimidine derivatives was carried out by various characterization techniques such as IR,¹H NMR, ¹³C NMR, LC-MS and Elemental analysis.

Conclusions: The outcome of this research brings to light the facile and efficient synthesis of novel compounds which provides a broader relevance for further development of the compounds as potent therapeutic agents.