Exploring Plant-Microbe Interactions in Rhizosphere: Novel Strategies for Drug Discovery from Medicinal Plants

Abstract

Background: Plant-microbe interactions in the rhizosphere play a pivotal role in plant health and adaptation, while medicinal plants are esteemed for their bioactive compounds with therapeutic potential. Understanding these interactions presents opportunities for novel drug discovery. Objective: This review aims to elucidate the interplay between plant-microbe interactions in the rhizosphere and the discovery of drugs from medicinal plants, highlighting mechanisms, challenges, and future prospects. Methods: A comprehensive literature review was conducted to examine the composition and dynamics of the rhizosphere microbiome, mechanisms of plant-microbe interactions, bioactive compounds in medicinal plants, and strategies for drug discovery. Results: The rhizosphere microbiome influences plant health and secondary metabolite production through nutrient exchange, induced systemic resistance, and signaling pathways. Medicinal plants harbor diverse bioactive compounds, yet accessing them poses challenges. Novel strategies such as bioinformatics and metagenomics offer promising avenues for drug discovery. Conclusion: Understanding plant-microbe interactions in the rhizosphere holds significant potential for discovering drugs from medicinal plants. Future research should focus on overcoming challenges and leveraging emerging technologies for sustainable drug discovery.