Management of Cerebral Palsy in LPS Induced Rat Model

Abstract

Introduction: Cerebral palsy (CP) is a complex neurological disorder linked to motor and cognitive impairments, often stemming from perinatal brain injury. Inflammatory processes play a role in CP, with animal models exposed to lipopolysaccharide (LPS) mimicking key features of the condition. Curcuma longa L (Turmeric), is known for its potent anti-inflammatory and antioxidant properties, is investigated for its potential neuroprotective effects in this study.

Objective: This study investigates about pro-inflammatory cytokines, oxidative stress markers, and neuroinflammatory pathways.

Material and Methods: The study administered LPS through the intracerebroventricular route in adult Wistar rats, with oral treatment of Curcuma longa L's hydroalcoholic extract (HAECL) in various doses. The investigation focused on pro-inflammatory cytokines, oxidative stress markers, and neuroinflammatory pathways. Behavioral tests and histological evaluations, including assessments of TNF-α, NF-κB, COX-2, IL-6, and neuronal viability, were conducted.

Results: The findings revealed that HAECL treatment significantly enhanced motor functions and reduced cognitive impairments, indicating improved learning and memory performance. Brain analysis showed decreased neuroinflammation and neuronal damage, suggesting neuroprotective properties. Oxidative stress markers were also attenuated, highlighting antioxidant effects.

Discussion: Curcuma longa L demonstrated notable neuroprotective effects, attributed to its anti-inflammatory and antioxidant properties. It mitigated motor deficits, preserved neuronal integrity, and reduced oxidative stress. The results position curcumin as a potential therapeutic agent for managing cerebral palsy-associated symptoms, warranting further investigation for clinical applications.