Antimicrobial Activity of Multi Drug Resistance Escherichia Coli Causing Urinary Tract Infection in Tertiary Care Hospital from Central India.

Abstract

Background: Escherichia coli can cause disease and is responsible for most community-acquired (as opposed to hospital-acquired) urinary tract infections (UTIs). Treatment can be complicated by antimicrobial resistance, particularly against extended-spectrum Cephalosporin’s. Increasingly, enzymes, such as AmpC beta-lactamases (ACBLs) and extended-spectrum beta-lactamases (ESBLs), have been reported in pathogenic bacteria, including E. coli. Resistance to beta-lactams is also associated with multidrug resistance.

Aim: The present study was conducted to evaluate the role of antimicrobial activity for UTI patients caused by ESBL and AmpC producing E. coli isolate.

Materials and Methods: This observational hospital-based study was conducted in the Department o f Microbiology, Index Medical College, Hospital and Research Centre Indore MP,

India. The study population included 1000 of all age. Clinically suspected cases of urinary tract infection were included. Antimicrobial susceptibility of isolates was tested for uropathogens by using Kirby Bauer disk diffusion method according to CLSI guide lines.

Results: Out of (83.4%) Escherichia coli sensitivity 19 (54.3%) were major ESBL producer. And 16 (45.7%) was the major AmpC producer Escherichia coli.

Conclusion: In c o n c l u s i o n , t h e p r e s e n t results suggest that the increasing drug-resistant isolates of ESBL producing E. coli to commonly used antibiotics like fluoroquinolones, cephalosporins and other β-lactams. This trend of rise in isolation of MDR uropathogens poses a challenge to the current armamentarium for the

treatment of UTIs.