Exploring the Potential Antidiabetic Effects of Ethanol Extract of Rhizome of Curcuma Angustifolia Roxb. In Streptozotocin-Induced Diabetic Rats
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Abstract
The study aimed to explore the potential of the ethanol extract of rhizome of Curcuma angustifolia Roxb. (Zingiberaceae) in managing diabetes using both normal and streptozotocin (STZ)-induced diabetic rat models. Administered orally over a 21-day period at doses of 250 and 500 mg/kg body weight, the extract's effects were compared with those of the known antidiabetic drug metformin (100mg/kg body weight). The results highlighted significant improvements across various parameters. Firstly, there was a notable increase in body weight among the treated rats, suggesting a positive impact on overall health and metabolic function. Liver glycogen levels also saw a marked increase, indicating enhanced glycogen storage and improved glucose metabolism. Moreover, serum insulin levels showed a significant rise, indicative of improved pancreatic function and insulin secretion. In terms of lipid profile, the ethanol extract demonstrated promising outcomes. There was a substantial decrease in blood glucose levels, pointing towards its hypoglycemic effect. Additionally, glycosylated hemoglobin levels were significantly reduced, reflecting better long-term glucose control. Notably, the extract led to a decline in both total cholesterol and serum triglycerides, key markers of dyslipidemia commonly associated with diabetes. Conversely, high-density lipoprotein (HDL) levels showed a significant increase, suggesting an improvement in lipid metabolism and cardiovascular health.