Exploring the Potential Antidiabetic Effects of Ethanol Extract of Rhizome of Curcuma Angustifolia Roxb. In Streptozotocin-Induced Diabetic Rats

Abstract

The study aimed to explore the potential of the ethanol extract of rhizome of  Curcuma angustifolia Roxb. (Zingiberaceae) in managing diabetes using both normal and streptozotocin (STZ)-induced diabetic rat models. Administered orally over a 21-day period at doses of 250 and 500 mg/kg body weight, the extract's effects were compared with those of the known antidiabetic drug metformin (100mg/kg body weight). The results highlighted significant improvements across various parameters. Firstly, there was a notable increase in body weight among the treated rats, suggesting a positive impact on overall health and metabolic function. Liver glycogen levels also saw a marked increase, indicating enhanced glycogen storage and improved glucose metabolism. Moreover, serum insulin levels showed a significant rise, indicative of improved pancreatic function and insulin secretion. In terms of lipid profile, the ethanol extract demonstrated promising outcomes. There was a substantial decrease in blood glucose levels, pointing towards its hypoglycemic effect. Additionally, glycosylated hemoglobin levels were significantly reduced, reflecting better long-term glucose control. Notably, the extract led to a decline in both total cholesterol and serum triglycerides, key markers of dyslipidemia commonly associated with diabetes. Conversely, high-density lipoprotein (HDL) levels showed a significant increase, suggesting an improvement in lipid metabolism and cardiovascular health.