Sugammadex – Reversal of Profound Neuromuscular Blockade in Laparoscopic Surgery

Abstract

Introduction- Sugammadex is a modified γ-cyclodextrin, which promptly reverses the steroidal nondepolarizing neuromuscular blocking agents. Methodology- This interventional trial was commenced after Institutional ethical committee approval in Tagore Medical College and Hospital. Written informed consent obtained from patients before starting the study. A total number of 30 patients of ASA 1,2 between age-18 – 60 years, undergoing laparoscopic surgery, willing to participate in the study was selected. Results-Around 43.3% subjects belonged to age group 20-30 years, 16.6% subjects from age group 31-40 years, 26.6 % from age group 41-50 years, and 13.3% subjects from age group 51-60 years. Among all patients, 12 males and 18 were females. Sugammadex hastened the recovery of DNMB 3.2 times that of rocuronium - induced recovery of conventional blockade and pressure (CNMB) and is advocated as a reversal agent for this procedure. Conclusion- Laparoscopic surgeries under Deep Neuromuscular Blockade (DNMB)/ Low Abdominal Insufflation Pressure (LIAP) procedure is feasible and safe with lower incidence and severity of shoulder tip pain (STP) and high surgeons’ satisfaction