Antineoplastic and Antioxidant Activity of Engineered Andrographolide Selenium Nanoparticles

Abstract

Introduction: Nanotechnology refers to any technological advancement that operates on the nanoscale and has diverse practical applications. Nanotechnology encompasses the creation and use of physical, chemical, and biological processes at scales that range from atoms to submicron dimensions.

Objectives: The objective of this research is to synthesize nanoparticles of selenium employing Andrographolide via an eco-friendly approach.

Methods: The green nanoparticles were analyzed by ultraviolet-visible spectroscopy, FT-IR, and TEM.

Results: The dimensions of the synthesized selenium nanoparticles (SeNPs) in Andrographolide were determined to vary between 12 and 160 nanometers, based on the analysis of transmission electron microscopy (TEM) images. The selenium nanoparticles exhibited antioxidant activity ranging from 66.7% to 83.7% in terms of their ability to block free radicals.

Conclusions: Higher nanoparticle concentration results in reduced cancerous cell viability. The presence of produced nanoparticles of selenium clearly demonstrates their ability to inhibit cancer growth, with the extent of this action depending on the dosage.