Formulation and Evaluation of Taste Masked Granules for Oral Suspension

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Kalyankar Tukaram, Shinde Nagoji, Upalkar Sapna, S. D. Deosarkar, Karhale Mukesh

Abstract

The goal of this study is to determine the drug-excipient compatibility using FT-IR spectroscopy, evaluate the pre-formulation factors of paracetamol and mefenamic acid, and then formulate granules that contain paracetamol and mefenamic acid in order to carry out evaluation studies on the formulated granules. The combination of paracetamol and mefenamic acid is a very helpful medication for the treatment of moderate pain in children who suffer from rheumatoid arthritis, osteoarthritis, discomfort including muscle pain and dental pain, as well as fever and headaches. In the course of this research, a total of nine different formulations, denoted by the letters F1 through F9, were created and tested largely for taste and drug release profile. The taste of the F8 formulation was deemed suitable for oral administration. The percentage of drug release was 99.32 0.34% for Paracetamol and 98.91 0.12% for Mefenamic Acid, respectively. F8 Formulation was examined for stability study up to 3 M at 45 °C 2 °C/75% RH 5% accelerated condition and was analysed for % Assay & % drug release. The powder for oral suspension has been substituted for the traditional dose form. Receiving the correct dose in the form of an oral suspension or solution might be challenging.

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