Formulation and Evaluation of Captopril Bilayer Floating Tablets with Natural Polymers

Abstract

Aim: Present study is formulations and evaluations of bilayered Captopril tablets by natural polymers

Method:  Bilayered Captopril tablets were prepared by direct physical compression method using Guar Gum, Xanthan Gum (Natural), Sodium bicarbonates has a gas generating agent. The developed bilayered tablets are evaluated for physicochemical characters, buoyancy in vitro study, drug content, drug dissolution, Kinetic models, and drug stability studies.

Results:  the results are showing satisfactory and within the limits. The bilayered tablets consisting of CIR3 and CSR4 showing good floating property and drug release was found in a sustained manner for 12 hours and follows Higuchi kinetics. The optimised CIR3 and CSR4 bilayered tablet was more stable at various storage conditions. 

Conclusion: Captopril bilayered floating tablets were developed successfully by natural polymers and were stable for three months.