Apigenin Inhibits Α-Amylase Activity in Alloxan Induced Type-2 Diabetic Rats

Abstract

Purpose: to study the inhibitory activity of alpha amylase, antidiabetic, antioxidant effects of flavonoid Apigenin in diabetic rats.

Methods: The effect of Apigenin on blood glucose and antioxidant activities were estmated in alloxan induced diabetic and treated rats. The α-amylase activity in the serum was assessed after oral administration of  7^th day, 14^th  day, and 21^st  days treatment of Apigenin.

Results: The Apigenin was reduced serum glucose, α-amylase levels and increased  antioxidant levels significantly (P<0.05) in Apigenin alone and combination with Metformin treated groups.

Conclusion: The present investigation concludes that flavonoid Apigenin, single drug and combination with Metformin was inhibited alpha-amylase activity, antioxidant and hypoglycemic effect in alloxan induced diabetes rats