Bacteriophage Therapy Targeting Enterococcus Faecalis in Endodontics: A Systematic Review.

Abstract

The most prevalent bacteria encountered in secondary persistent endodontic infections is Enterococcus faecalis(E.Faecalis). The fundamental objective of any root canal treatment is to disinfect the root canal system in order to prevent microbial regrowth inside the root canal system. This makes E.Faecalis removal imperative. Because of the scarcity of therapeutic options for patients who are resistant to standard antimicrobials, there has been a renaissance of interest in (bacteriophage) treatment in recent years. The main aim of this review is to embark on a qualitative analysis of existing data on the antibacterial potential of bacteriophage therapy in the eradication of E. faecalis from the root canal system as a whole. Considering all the papers published till July 2023, a search of the databases PubMed, SCOPUS, and EBSCOhost was conducted. All of the English-language articles were included. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist guided the review process. After the data was extracted, the risk of bias was examined. Five Ex-vivo studies were included in the systematic review after assessing the distinguishing 46  studies according to the inclusion criteria.