Neuroimmunomodulation in Epilepsy: A review

Abstract

Epilepsy, also known as seizure disorder, is known to trigger lasting inflammatory reactions. Seizures are documented to cause brain inflammation through the stimulation of several neuronal and non-neuronal brain cells; It, in turn, aids in the structural and molecular alterations that take place during and after a seizure. When an inflammatory response begins, agents that promote inflammation, such as tumor necrosis factor (TNF) and interleukin (IL)-1, are released into the bloodstream. Aggravation has been demonstrated to be a significant figure in the advancement of epilepsy in both old and new examinations. Research into epileptogenesis's inflammatory pathways has uncovered potential new antiepileptic drugs' molecular targets. It is possible that molecules that target the key inflammatory pathways might be effective in preventing epilepsy. The present paper reviews and documents the correlation between neuroimmunomodulation and epilepsy and the potential role of related inflammatory molecules.