Formulation and Evaluation of Nebivolol Loaded Nanosponges for Oral Drug Delivery.

Abstract

Nanosponges, characterized by their nanosized structures capable of encapsulating both hydrophilic and hydrophobic drugs, present a promising avenue for overcoming challenges associated with drug delivery, such as poor oral bioavailability. In this study, the focus was on formulating and evaluating Nebivolol-loaded nanosponges using the Emulsion Solvent Evaporation method with ethyl cellulose, PVA, β-Cyclodextrin, and dichloromethane as key components. FTIR analysis confirmed the absence of interactions between the drug and polymers. The Nebivolol nanosponges were assessed for various parameters including drug entrapment efficiency, particle size, surface morphology, and Zeta potential. Subsequently, Nebivolol-loaded capsules were subjected to a battery of tests including weight variation, in vitro disintegration, drug content, in vitro dissolution, and stability studies. The results demonstrated controlled release behavior over 24 hours, with zero-order kinetics observed. The study suggests that Nebivolol nanosponges hold promise for controlled drug delivery applications.