Fabrication and Evaluation of Mesoporous Silica Nanoparticles Loaded with Adiantum Philippines Fraction and Thuja Oil as a Wound Healing Agent.

Abstract

Background: The research focuses on developing Mesoporous Silica Nanocarriers for delivering Adiantum Philippines and Thuja Oil, aiming to enhance their therapeutic effects.

Methods: The study meticulously formulates MSNs loaded with Adiantum Philippines and Thuja Oil. The MSNs were prepared using the method described by Fayez Hamam. Detailed characterization of the nanoparticles is performed for Particle size, morphology, entrapment efficiency, drug release properties, FTIR, and DSC studies.

Results: The results reveal a significant entrapment efficiency of 83.38 ± 0.26% for the APTO-MSNs, indicating a high level of Adiantum Philippines and Thuja Oil encapsulation within the nanocarriers. The in-vitro drug release profile over 12 hours is noteworthy, with a gradual and controlled release pattern, culminating in a peak release of 93.33%. These findings highlight the efficiency of MSNs in maintaining a sustained release of the loaded substances.

Conclusion: The study concludes that MSNs are an effective delivery system for Adiantum Philippines and Thuja Oil, enhancing their therapeutic efficacy. The research suggests potential applications in pharmaceuticals, particularly in improving the delivery and effectiveness of natural therapeutic agents.