Hepatic Hazards of Quantity and Duration of Alcohol Consumption Patients Attending De-Addiction Tertiary Level Teaching Hospital Jharkhand

Abstract

Objective: To study the correlation between duration and quantity of alcohol consumption with biochemical markers and radiological liver function tests in patients coming to tertiary level psychiatric h.

Methods: The study included 1030 patients with a history of alcohol consumption for more than 3 years, presenting to the Central Institute Psychiatry, Radiology Department, Ranchi, Jharkhand, from January 2023 to December 2023. All the male patients in the adult age group with more than 3 years of alcohol consumption were included in this study. A complete hemogram, liver function, and lipid profile were done in each patient. Liver ultrasonography was also conducted. Alcohol Use Disorders Identification Test Results (AUDIT) assessment of excessive alcohol use was done. Results:  14.56 % of patients had hemoglobin < 12 gm., with only 50% of patients having TLC count within the normal range. MCV < 100 was seen in 72.9%, biochemical jaundice in 45.72%, and raised serum GGT in 83%, SGOT in 78.05%, and SGPT in 47.08% was seen. Fatty liver in 67.08% and hepatomegaly in 74.07% were seen in this study. A significant correlation of > 80gm alcohol per day with De arranged liver function test, lipid profile, and radiological findings was observed in this study.

Conclusion:  A significant correlation between the quantity and duration of alcohol with liver function tests, biochemical blood markers, and lipid derangements was found in this study. Primary and secondary prevention of alcohol-induced hepatic injury can be done with early detection of the same with blood markers.