Salivary Uric Acid and Catalase Levels in Diabetes

Abstract

is associated with changes in antioxidant enzyme systems and total antioxidant capacity.

Objective : The aim of this study was to analyse the uric acid and catalase levels in the saliva of patients with type 2 DM and compare them with the healthy control group.

Methods: In this study, 20 patients with diabetes and 20 healthy individuals were evaluated. Salivary antioxidants markers consisted of uric acid (UA) and catalase. Sialo Chemical analysis was performed with spectrophotometric assay. Values were obtained and all the statistical analyses were conducted using SPSS software.

Results : Salivary Uric acid (3.12 vs. 1.89 mg/dL) was significantly higher (P < 0.001) in patients with DM than healthy controls. Mean UA was approximately 1.7 times higher in diabetic patients than in healthy controls. The antioxidant enzyme catalase showed significantly lower values in the study group than the controls ((1214 vs. 9468.9 kat, P < 0.001), drastic reduction in catalase activity was seen in diabetic samples. The present study demonstrates that antioxidant levels in saliva from diabetic patients exhibit significant differences compared to control samples.

Conclusion: According to the findings of the current study, patients with type 2 DM showed some alterations in their salivary levels of uric acid and catalase which suggests that there is increase in the oxidative stress levels.