Exploring Traditional Wisdom: Antipsychotic Properties of Ethano Medicinal Plants in the Cucurbitaceae Family

Abstract

Psychosis is a frequent and severely handicapping symptom of many psychiatric, neurodevelopmental, neurologic, and medical diseases. Schizophrenia is a mental illness that results in abnormal behaviours, decreased affect, and altered thought and perception. The neurotransmitter most closely linked to the pathogenesis of psychotic illnesses is dopamine. Dopamine overproduction in the mesolimbic tract is thought to be the main factor of the positive symptoms of psychotic disorders. Additionally involved is glutamate, an excitatory neurotransmitter. The leguminous plant Mucuna pruriens (MP), which thrives in all tropical regions and contains levodopa, was looked into as a possible levodopa substitution for Parkinson's disease sufferers. Polyphenols found in herbal drugs contribute to this regulation of depression. Clinical studies suggest that proinflammatory cytokines, those are available in polyphenols, may contribute to the pathophysiology of depression. According to a phytochemical examination of numerous secondary metabolites, phytocomponents include anthraquinone, flavonoids, steroids, tannins, saponins, alkaloids, terpenoids, and cardiac glycosides are present.