Diabetic Wound Healing: Interplay of Genetic Predisposition, Environmental Exposures, Lifestyle Choices, and Ethnicity in Therapeutic management

Abstract

Diabetic wound healing is a complex process influenced by various factors including genetic predisposition, environmental exposures, lifestyle choices, and ethnicity. This review explores the intricate interplay of these elements in the treatment of diabetic wounds. Genetic predispositions, such as variations in genes involved in inflammation and angiogenesis, can significantly impact an individual's susceptibility to diabetic wound complications. Environmental exposures, including pollutants and microbial pathogens, further exacerbate wound healing challenges in diabetic patients. Lifestyle choices such as diet, exercise, and smoking habits play a crucial role in modulating wound healing outcomes. Additionally, ethnicity contributes to variations in wound healing rates and responses to treatment due to genetic and cultural factors. Understanding these multifaceted influences is essential for tailoring effective diagnostic and therapeutic approaches for diabetic wound management. Integrating personalized medicine strategies with culturally sensitive healthcare practices can enhance outcomes and reduce the burden of diabetic wounds on affected individuals and healthcare systems.