Development and in Vitro Evaluation of Paliperidone Floating Tablets Using Natural Polymers

Abstract

Aim: the aim of the present study was formulation and evaluation of the floating tablets of Paliperidone with natural polymers

Method:  The floating drug delivery system of Paliperidone tablets were prepared by direct physical compression method using Guar Gum and Xanthan gum as Natural polymers and Sodium bicarbonates as a gas generating agent. All the formulations were evaluated for physicochemical parameters, in vitro buoyancy, drug content, in vitro dissolution, Kinetic models, drug stability studies.

Results:  the results were found within the limits for all formulations. Among all the formulation F4 showed the better buoyancy, drug release profiles. The release of drug from the prepared formulations (F4) was found to follows Higuchi kinetics., and it was more stable at various storage conditions. 

Conclusion: Paliperidone floating tablets were successfully developed by natural polymers and was stable for three months.