Nanosponge Application in Burn Wound Models for Enhanced Wound Healing: A Review

Abstract

Specialized institutions focus on stabilization, infection control, and functional rehabilitation for burn patients, making them a major critical care concern. Burns research has resulted to better patient stabilization and lower fatality rates, especially for younger patients and those with moderate burns. However, patients in the intensive care unit encounter unique difficulties that make assistance and stabilization more difficult. Wounds from fires are difficult to treat, and sometimes even late intervention or lifetime rehabilitation is needed. Recent studies have led to improvements in burn wound treatment that will lead to enhanced functional recovery. Curcumin, a naturally occurring polyphenolic compound, has been employed in Ayurvedic medicine for thousands of years due to its anti-inflammatory and wound-healing effects. Curcumin's ability to eliminate ROS, boost collagen deposition, granulation tissue production, and wound contraction has been shown in several scientific studies. However, curcumin's potential in wound healing has been limited by its poor solubility, quick metabolism, and shorter plasma half-life. By encouraging the right kind of mobility throughout the different stages of wound healing, nanotechnology has shown to be an efficient method for hastening recovery time. Nano-carriers loaded with curcumin are utilized to specifically target wounds for drug delivery. Curcumin and its nano-formulations have been discussed in this review for its potential in promoting wound healing.